Vittorio Unfer

Dear Editor,
I read with extreme interest and curiosity the recent overview of the use of inositols – D-chiro-inositol, in particular – as treatment for women with polycystic ovary syndrome (PCOS). After remaining dormant for many years, a keen interest
towards the physiological roles of D-chiro-inositol has recently resurfaced, fuelling clinical and pre-clinical studies that evaluated the potential benefits of supplementation regimens. In particular, applications for gynecological conditions have received special attention, despite some of the available investigations produced inconclusive results (mostly due to heterogeneous selection of the study population) that led to biased conclusions and illogical indications for treatments.